Figure 5
Triple combination of adjuvant aflibercept, perioperative BowAng1 and adjuvant paclitaxel therapies for resected breast cancer.
18 days after orthotopic implantation of 2 × 106 LM2-4 cells, mice bearing approximately 200-mm3 primary breast tumors were randomized into four treatment groups. Primary tumor resections by complete mastectomies were performed at 20 days post-implantation (DPI). BowAng1 was given as a 10-day perioperative therapy, beginning one day before surgery (19 DPI). Aflibercept (anti-VEGF-A/VEGF-B/PlGF) and paclitaxel chemotherapy were given as 4-week-long adjuvant therapies, starting two days after surgery (22 DPI). Dosing schedule is depicted above Kaplan-Meier survival curves (n = 10 mice per treatment group). The log-rank statistical test was used to assess differences in overall survival between treatment groups at two timepoints: 80 DPI (interim) and 115 DPI (final) respectively.
