Table 3 Standardized regression coefficients of serum Nrg4 levels and metabolic risk factors for predicting carotid intima-media thickness and atherosclerotic plaque.

From: Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults

Independent variables

Unadjusted

Adjusted §

β

SE

P-value

β

SE

P-value

CIMT

 BMI

0.0001

0.007

0.984

−0.002

0.009

0.867

 Systolic BP

0.031

0.007

<0.001

0.023

0.007

0.001

 Total cholesterol

0.031

0.007

<0.001

0.025

0.007

<0.001

 HDL-cholesterol

−0.024

0.007

<0.001

−0.014

0.008

0.069

 Fasting glucose

0.026

0.007

<0.001

0.022

0.008

0.004

 Serum Nrg4

−0.024

0.006

<0.001

−0.022

0.006

<0.001

 Model R2 (%)

0.194

  

0.267

  

Atherosclerotic plaque

 BMI

−0.045

0.020

0.030

−0.046

0.027

0.088

 Systolic BP

0.055

0.021

0.008

0.021

0.021

0.315

 Total cholesterol

0.068

0.021

0.001

0.054

0.021

0.008

 HDL-cholesterol

−0.039

0.021

0.062

−0.037

0.022

0.103

 Fasting glucose

0.008

0.021

0.440

−0.026

0.022

0.238

 Serum Nrg4

−0.036

0.019

0.062

−0.039

0.019

0.037

 Model R2 (%)

0.061

  

0.156

  
  1. CIMT = carotid intima-media thickness; BMI = body mass index; HOMA-IR = homeostasis model assessment of insulin resistance; Nrg4 = Neuregulin 4; β = standardized regression coefficient; SE = standard error.
  2. §Adjusted for age, sex, smoking, physical activity, HOMA-IR, and body fat.
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