Figure 4

Effects of cold stress in PM0 and SP.MES.

Effects of cold stress on SBP: Numbers of rats used were 5 PM0 and 3 SP.MES. (a) The time course of BP changes is shown (b) SBP at room temperature (RT) and under cold stress (CS) are summarized (c) increase in SBP under cold stress (ΔSBP). *Significantly lower than SBP in PM0. Effects of cold stress on u-NE: Numbers of rats used are 7 PM0 and 5 SP.MES. (d) u-NE at room temperature (RT) and under cold stress (CS) are summarized (e) increase in u-NE under cold stress (Δu-NE). *Significantly different from the level in PM0. RT; room temperature, CS; cold stress, u-NE; urinary norepinephrine, SBP; systolic blood pressure. (f) Effect of losartan on response to cold stress in SHRSP. Response to cold stress was examined with and without losartan infused into the lateral ventricle. Numbers of rats used were 3 in each experiment. *Significantly different from Los (−). Los: losartan. The Student’s t-test was applied in the analyses.