Figure 1
From: 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium
2-AB reflects excessive load conditions in hearts.
(a) 2-AB levels in serum in healthy volunteers (n = 11) and ASD patients before (pre) and after (post) transcatheter closure (n = 8). (b) Correlation between 2-AB concentration and TRPG score. c, Illustration of stretch assay. H9c2 cells were stretched by 10% for 1 h. d, e, Mechanical stress induces 2-AB production by cells (c) and can be detected in the culture medium (d). (e) H2O2 increased intracellular levels of GSH in the cells. 2-AB, 2-aminobutyric acid; ASD, atrial septal defect; TRPG, tricuspid regurgitation peak gradient. *P < 0.05. P-values were determined by unpaired two-tailed Student’s t-tests.
