Table 3 Deregulated genes residing at drug resistance related clusters.
Gene ID | Fold change | Functional cluster |
|---|---|---|
ABCB1 | 402.36 | Cancer drug resistance, drug metabolism, drug transporters |
PDLIM1 | 270.42 | Oxidative stress |
FZD7 | 161.27 | WNT signaling |
CCND2 | 101.35 | Stem cell, WNT signaling |
FOXO1 | 80.08 | Transcription factors |
HMOX1 | 71.71 | Oxidative stress |
PRKCA | 70.94 | Oncogenes and tumour suppressors |
LRP5 | 31.80 | WNT signalling |
CXADR | 30.35 | WNT signalling |
GZMA | 29.25 | Drug metabolism, phase I |
NEIL2 | 22.35 | DNA repair |
TST | 21.91 | Drug metabolism, phase II |
DTX1 | 17.47 | Stem cell |
IGF1R | 14.60 | Cancer drug resistance |
SLC2A3 | 13.64 | Drug transporters |
CYP27B1 | 13.23 | Drug metabolism, phase I |
PON2 | 12.25 | Drug metabolism |
ABCG2 | 12.24 | Cancer drug resistance, drug transporters, stem cell |
ABCA2 | 10.50 | Drug transporters |
BNIP3 | 10.41 | Oxidative stress |
BBC3 | 10.26 | DNA damage |
GATA2 | 9.65 | Transcription factors |
COL1A1 | 8.56 | Stem cell |
DNAJC15 | −498.95 | Heat shock |
HSPH1 | −101.26 | Heat shock |
AS3MT | −99.20 | Drug metabolism, phase II |
TCF7 | −17.66 | WNT signalling |
CD44 | −14.89 | Stem cell |
SLCO3A1 | −12.43 | Drug transporters |
POU2AF1 | −10.32 | Transcription factors |
SLC25A13 | −9.88 | Drug transporters |
CD8A | −7.80 | Stem cell |
