Figure 7
Schematic representation of PNC formation induced by S. suis.
The Ca2+ influx across transmembrane pores created by SLY, the cholesterol-dependent cytolysin (CDC) of S. suis, triggers the Ca2+-MLCK and the “outside-in” signalling, leading to α-granules (P-selectin) release to the platelets surface. Subsequently, P-selectin mediates the platelet adhesion to neutrophils to form PNC.
