Table 1 The profile of thyroid hormones in mouse offspring born after NC and high E2 exposure during early pregnancy.

From: Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring

 

3 weeks

8 weeks

NC (n = 7)

Ev10 (n = 6)

Ev100 (n = 6)

NC (n = 7)

Ev10 (n = 6)

Ev100 (n = 6)

female

 T3 (ng/ml)

0.77 ± 0.08

0.78 ± 0.12

0.78 ± 0.13

0.87 ± 0.03

0.86 ± 0.06

0.87 ± 0.04

 FT3 (fmol/ml)

2.77 ± 0.33

2.71 ± 0.29

2.69 ± 0.43

2.76 ± 0.18

2.72 ± 0.25

2.99 ± 0.22

 T4 (ng/ml)

45.68 ± 4.08

49.36 ± 3.12

63.74 ± 5.41**

49.92 ± 2.93

53.38 ± 2.52

61.68 ± 2.55*

 FT4 (fmol/ml)

11.43 ± 1.11

13.20 ± 1.16

15.93 ± 1.28*

11.63 ± 0.70

12.58 ± 0.63

14.37 ± 0.52*

 TSH (mIU/L)

1.81 ± 0.11

1.71 ± 0.13

1.68 ± 0.11

1.84 ± 0.15

1.76 ± 0.16

1.69 ± 0.13

male

 T3 (ng/ml)

0.61 ± 0.06

0.63 ± 0.09

0.61 ± 0.09

0.92 ± 0.04

0.88 ± 0.05

0.82 ± 0.03

 FT3 (fmol/ml)

3.47 ± 0.34

3.49 ± 0.24

3.52 ± 0.26

2.69 ± 0.31

2.73 ± 0.29

2.55 ± 0.13

 T4 (ng/ml)

50.32 ± 2.46

52.67 ± 2.75

57.98 ± 3.97*

49.91 ± 2.27

51.22 ± 2.06

52.34 ± 3.89

 FT4 (fmol/ml)

12.03 ± 1.16

12.65 ± 1.08

13.62 ± 0.71

12.45 ± 0.67

13.12 ± 0.69

12.73 ± 1.23

 TSH (mIU/L)

1.89 ± 0.13

1.81 ± 0.09

1.78 ± 0.15

1.91 ± 0.11

1.83 ± 0.15

1.89 ± 0.12

  1. Data are shown as mean ± SE, *P < 0.05 or **P < 0.01 vs. NC.
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