Table 1 Binding affinities and selectivity of complex 1 for various oligonucleotides, determined by the FID assay.

From: Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex

 

DC50a (μM)

Selectivity against ds26b

HTelo

1.01 (0.03)

9.81

KRAS m(1:5:1)

2.28 (0.10)

4.34

KRAS m(1:9:1)

2.35 (0.09)

4.22

c-Kit

3.58 (0.28)

2.77

c-Myc

7.15 (0.17)

1.39

ds26

9.91 (0.55)

HIF1α

10.20 (0.54)

0.97

hTERT

10.51 (0.61)

0.94

VEGF

11.58 (0.41)

0.86

  1. aStandard deviation (n = 4) are shown in parentheses.
  2. bRatio of DC50 for oligonucleotides against ds26.