Figure 3 | Scientific Reports

Figure 3

From: Protein tyrosine phosphatase PTPN3 promotes drug resistance and stem cell-like characteristics in ovarian cancer

Figure 3

Silencing of PTPN3 inhibits resistant ovarian cancer cell growth, migration and drug resistance.

(A,B) MTS assay results showing that cell growth was dramatically reduced by silencing PTPN3 in both A2780CIS (A) and A2780ADR (B) cells. (C,D) The Transwell migration assay showed that silencing PTPN3 significantly suppressed the migration rates of both cisplatin and doxorubicin resistant ovarian cancer cells. Scale bar = 100 μm. (E,F) MTS assay results showing that silencing PTPN3 significantly contributed to increasing the sensitivity of resistant ovarian cancer cells to cisplatin (E) and doxorubicin (F). *P < 0.05 (t test).

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