Table 2 Univariate and Multivariate Cox regression analyses for overal survival of gastric cancer.

From: High Hepsin expression predicts poor prognosis in Gastric Cancer

Factors

Univariate

Multivariate

HR (95%CI)

P-value

HR (95%CI)

P-value

Age

 

0.0513

  

 ≤60

1.00 (reference)

   

 >60

1.456 (0.997–2.124)

   

Gender

 

0.7384

  

 Female

1.00 (reference)

   

 Male

0.934 (0.625–1.394)

   

Localisation

 

0.214

  

 Distal

1.00 (reference)

   

 Middle + Proximal

1.288 (0.864–1.920)

   

Differentiaon

 

0.6104

  

 Well + Moderately

1.00 (reference)

   

 Poorly

0.883 (0.547–1.425)

   

Lauren classification

 

0.7496

  

 Intestinal

1.00 (reference)

   

 Diffuse + Mixed

0.945 (0.621–1.409)

   

T classification

 

<0.001

 

0.016

 T1 + T2

1.00 (reference)

 

1.00 (reference)

 

 T3 + T4

3.445 (2.290–5.181)

 

3.094 (1.230–7.782)

 

N classification

 

<0.001

 

0.645

 N0

1.00 (reference)

 

1.00 (reference)

 

 N+

3.145 (2.117–4.673)

 

1.250 (0.484–3.226)

 

Distant metastasis

 

<0.001

 

<0.001

 No

1.00 (reference)

 

1.00 (reference)

 

 Yes

40.7 (11.21–147.8)

 

3.241 (1.698–6.185)

 

TNM stage

 

<0.001

 

0.011

 I + II

1.00 (reference)

 

1.00 (reference)

 

 III + IV

4.544 (3.104–6.654)

 

2.899 (1.280–6.566)

 

Intravascular cancer emboli

 

0.0024

 

0.815

 No

1.00 (reference)

 

1.00 (reference)

 

 Yes

1.982 (1.275–3.082)

 

1.049 (0.702–1.567)

 

Hepsin expression

 

0.0014

 

0.036

 Low

1.00 (reference)

 

1.00 (reference)

 

 High

1.913 (1.284–2.850)

 

1.498 (1.026–2.185)

 
  1. Abbreviation: 95% CI = 95% confidence interval; HR = hazard ratio; TNM = tumour node metastasis; P-value < 0.05 marked in bold font shows statistical significant.
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