Figure 5 | Scientific Reports

Figure 5

From: V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca−/− mice

Figure 5

Fanca−/− mice displayed a skewed Vκ gene usage in in-frame Vκ-Jκ1 rearrangements in BM IgM- B cells.

Analysis of Vκ gene family usage of total (A) and in-frame (B) Vκ-Jκ1 rearrangements amplified from genomic DNA isolated from BM IgM− B cells of Fanca−/− and WT mice (*p < 0.05 with Fisher’s exact test). Vκ families are displayed according to chromosomal order relative to the Jκ genes cluster. The data are from four independent pools of four mice per genotype (numbers of analysed sequences are indicated in Table 1).

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