Table 1 Cytokines and chemokines levels in lungs of susceptible A/J and resistant C3H/HeOuJ mice during time course of P. aeruginosa chronic lung infection.

Cytokines	naïve		Day2		Day7		Day14		A/J vs C3H/HeOuJ
Cytokines	A/J	C3H/HeOuJ	A/J	C3H/HeOuJ	A/J	C3H/HeOuJ	A/J	C3H/HeOuJ	naive	Day2	Day7	Day14
IL1α	0,54	1,55	205,70	150,30	201,20	50,38	18,88	12,95	ns	ns	*	ns
IL1β	10,73	3,80	214,60	116,70	322,70	90,37	25,76	20,62	ns	*	**	ns
IL6	0,62	0,62	11,94	0,62	2,99	0,62	0,62	0,62	ns	*	ns	ns
MCP1	11,10	1,24	191,80	49,27	6,87	9,12	1,24	1,24	ns	*	ns	ns
MIP1α	0,10	0,10	165,00	96,38	72,71	27,50	4,30	1,69	ns	*	*	ns
MIP1β	9,10	9,44	66,05	32,07	47,07	22,59	16,97	15,82	ns	*	*	ns
TNFα	3,16	3,16	12,05	3,16	3,25	3,16	3,16	3,16	ns	ns	ns	ns
KC	6,61	7,13	181,30	102,00	73,10	33,49	13,84	7,91	ns	*	ns	ns
G-CSF	3,84	1,93	386,80	126,70	31,01	18,63	5,06	2,71	ns	*	ns	ns
IFNγ	nd	nd	nd	nd	nd	nd	nd	nd	—	—	—	—
IL2	nd	nd	nd	nd	nd	nd	nd	nd	—	—	—	—
IL12p70	1,74	1,74	53,63	17,61	14,32	1,74	1,74	1,74	ns	ns	*	ns
IL17A	4,44	4,54	8,63	8,10	20,53	7,13	6,44	7,50	ns	ns	**	ns
IL12p40	1,62	1,77	57,61	20,32	109,00	36,01	25,95	9,69	ns	*	**	ns
IL23p19	0,04	0,04	0,09	0,08	0,09	0,05	0,10	0,08	—	—	*	—
IL21	0,06	0,05	0,09	0,08	0,10	0,07	0,10	0,09	—	—	*	—
IL22	0,00	0,00	0,01	0,01	0,01	0,01	0,01	0,01	—	—	—	—
IL10	0,60	0,31	11,93	5,34	3,90	2,01	0,92	1,70	ns	*	ns	ns

Data are expressed as mean of pg/500 μg lung. Statistical analysis for comparison of A/J vs C3H/HeOuJ by the non-parametric Mann-Whitney U test and by nonparametric Kruskal-Wallis test is indicated followed by post-hoc Dunn test to correct for multiple comparisons for a specific murine strain across multiple time-points (*p < 0.05, **p < 0,01) is reported. In bold significance of each value compared with its naïve counterpart. nd: not detectable; ns: not significant.

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