Figure 1 | Scientific Reports

Figure 1

From: Activation of Protein Kinase G (PKG) Reduces Neointimal Hyperplasia, Inhibits Platelet Aggregation, and Facilitates Re-endothelialization

Figure 1

Effects of Exisulind on neointimal formation after balloon injury in rat carotid arteries.

(A) Representative figures of the vessels at 2 weeks after injury. Exisulind treatment significantly reduced neointimal hyperplasia compared to vehicle-treated group. I = Intima, M = Media. Scale bar = 100 μm. (B) Quantification graphs of Intima to Media (I/M) ratio and intimal area at 2 weeks after injury. This graph shows markedly reduced I/M ratio and intimal area in Exisulind-treated group (n = 10 per group). *P < 0.01 vs. control, **P < 0.01 vs. control. (C,D) Representative figures and quantification of vascular proliferation performed at day 7 after arterial injury by BrdU incorporation in rats. Exisulind treatment reduced BrdU-positive cells compared to vehicle-treated group. *P < 0.01 vs. control, **P < 0.01 vs. control.

Back to article page