Table 3 KEGG pathway enrichment of DEGs for miRNAs and lncRNAs.

From: mRNA changes in nucleus accumbens related to methamphetamine addiction in mice

Pathways

miRNAs-DEGs

lncRNAs-DEGs

EF1

P-value2

DEmiRs3

EF

P-value

DElncRs4

Nicotine addiction

   

6.59

2.06E-06

522

Long-term potentiation

   

6.40

2.98E-12

869

Cocaine addiction

3.58

2.56E-02

3

   

Amphetamine addiction

3.20

2.16E-03

7

4.61

6.47E-08

772

Glutamatergic synapse

2.68

4.44E-03

5

4.75

2.20E-10

980

Retrograde endocannabinoid signaling

   

4.61

6.47E-08

745

Endocrine and other factor-regulated calcium reabsorption

   

3.84

2.63E-04

431

Morphine addiction

2.61

1.22E-02

7

3.14

7.61E-04

543

GnRH signaling pathway

2.44

1.23E-02

4

   

Long-term depression

2.34

4.43E-02

4

3.70

1.85E-04

449

Dopaminergic synapse

2.20

1.65E-02

5

4.35

2.88E-10

946

Calcium signaling pathway

   

3.39

1.04E-07

1083

GABAergic synapse

   

3.01

1.09E-03

561

Synaptic vesicle cycle

   

2.99

1.17E-03

494

Cholinergic synapse

   

2.98

4.43E-04

603

MAPK signaling pathway

2.07

2.40E-03

9

2.32

2.41E-05

1119

Neurotrophin signaling pathway

   

2.27

1.48E-03

692

Alzheimer’s disease

   

2.09

5.92E-03

603

Axon guidance

   

2.08

2.19E-03

861

Regulation of actin cytoskeleton

   

2.04

1.17E-04

1225

ErbB signaling pathway

   

3.46

2.94E-05

678

Insulin signaling pathway

   

2.89

1.41E-05

783

Phosphatidylinositol signaling system

   

2.67

1.86E-03

537

Wnt signaling pathway

   

2.34

1.07E-03

728

VEGF signaling pathway

   

2.19

2.26E-02

425

Adherens junction

   

2.76

9.02E-04

541

Focal adhesion

   

2.21

8.30E-05

1034

Gap junction

   

2.19

3.03E-02

377

Type II diabetes mellitus

   

3.67

3.85E-04

460

Ubiquitin mediated proteolysis

   

2.24

2.32E-03

661

Fatty acid elongation

9.31

4.07E-05

2

   

Cysteine and methionine metabolism

3.74

1.10E-02

5

   

Oxidative phosphorylation

3.06

4.83E-03

5

   

Biosynthesis of secondary metabolites

2.24

9.44E-04

10

   

Arginine and proline metabolism

3.41

8.57E-03

4

   

Vibrio cholerae infection

3.03

3.11E-03

4

2.59

8.01E-03

459

mTOR signaling pathway

2.73

2.35E-02

3

3.63

4.22E-04

554

T cell receptor signaling pathway

   

2.27

7.06E-03

580

B cell receptor signaling pathway

   

2.20

1.62E-02

429

Protein export

9.09

2.05E-04

3

   

Ribosome

3.15

1.40E-03

4

   

Spliceosome

2.43

4.25E-03

3

   
  1. 1Indicated enrichment factor.
  2. 2P values were calculated via hypergeometric tests and go with a correction.
  3. 3Indicated number of differentially expressed miRNAs17.
  4. 4Indicated number of differentially expressed lncRNAs18.
Back to article page