Table 1 Cardiac parameters measured by Millar Catheter.

From: TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

 

TRPC3(+/+) sham (n = 6)

TRPC3(−/−) sham (n = 6)

TRPC3(+/+) TAC (n = 13)

TRPC3(−/−) TAC (n = 10)

Heart Rate (bpm)

410 ± 6

400 ± 4

393 ± 6

402 ± 3

LVESP (mmHg)

135 ± 1

151 ± 5

180 ± 10**

232 ± 11##

LVEDP (mmHg)

0.8 ± 0.5

1.4 ± 0.9

5.4 ± 0.7**

2.7 ± 1.1#

dP/dt max (mmHg/sec)

10503 ± 531

12288 ± 354

8552 ± 282*

12750 ± 802##

dP/dt min (mmHg/sec)

7298 ± 104

8201 ± 341

6598 ± 381

8122 ± 466

tau (msec)

12.5 ± 0.3

12.1 ± 0.4

16.0 ± 0.9*

13.5 ± 0.8#

  1. HR, heart rate; LVESP, left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure; dP/dt max, maximal rate of pressure development; dP/dt min, maximal rate of decay of pressure; tau, monoexponential time constant of relaxation.
  2. Data are mean ± s.e.m. *P < 0.05, **P < 0.01 v.s. TRPC3 (+/+) sham, and #P < 0.05, ##P < 0.01 vs. TRPC3 (+/+) TAC.
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