Figure 2 | Scientific Reports

Figure 2

From: Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats

Figure 2

Microarray analysis of gene expression measured in the rat NAc at 2 hours after cessation of methamphetamine self-administration and footshocks.

(a) Comparison of microarray results of pairwise comparisons between shock-resistant and control (SRvsCT), shock-resistant and shock-sensitive (SRvsSS), and shock-sensitive and control (SSvsCT). There were 11, 23, and 6 differentially expressed genes in the SRvsCT, SRvsSS, and SSvsCT comparisons, respectively. The number of up- and down-regulated genes for each comparison is shown in red and green, respectively. (b) Ingenuity pathway analysis shows that differentially expressed genes in the SRSS comparison are involved in activation of cells and disorders of the basal ganglia. The networks and functional analyses were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA®, QIAGEN Redwood City, www.qiagen.com/ingenuity).

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