Figure 4 | Scientific Reports

Figure 4

From: Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats

Figure 4

Effects of methamphetamine self-administration and footshocks on the expression of PDYN and RENK expression in the NAc.

qPCR experiments were conducted using individual RNA samples from the NAc of rats that fell within the 3 groups. Values are means + SEM in comparison to the control animals. The shock-resistant phenotype showed significant increases in (A) PDYN and (B) PENK mRNA levels, replicating the microarray data. N = 6 per group. *p < 0.05, **p < 0.01, in comparison to the control group; ##p < 0.01, in comparison to the shock-resistant phenotype.

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