Figure 5 | Scientific Reports

Figure 5

From: Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats

Figure 5

Effects of methamphetamine self-administration and footshocks on the expression of Nr4a and Egr classes of immediate-early genes.

qRT-PCR experiments were conducted as described in Fig. 4. Values are means + SEM in comparison to the control animals. (A,B) There were no significant changes in the expression of Nr4a1 and Nr4a2 between the groups. (C) The shock-resistant rats showed significantly higher Nr4a3 expression than the shock-sensitive animals. (D,E) There were no significant differences in the expression of Egr1 and Egr2 expression between the 3 groups. (F) The shock-resistant phenotype showed higher Egr3 expression than the control and shock-sensitive phenotype. N = 6 per group. *p < 0.05, in comparison to the control group; #p < 0.05, in comparison to the shock-resistant SR rats. Note the differences in the y-axis scale for Egr3 expression in comparison to the other genes in the figure.

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