Table 1 Classification of genes with altered expression after methamphetamine self-administration and footshocks in the NAc.

From: Increased expression of proenkephalin and prodynorphin mRNAs in the nucleus accumbens of compulsive methamphetamine taking rats

GenBank/RNA Accession number

Gene Symbol

Gene Name

Fold change ratio SR/CT

Fold change ratio SS/CT

Fold change ratio SR/SS

Membrane

 NM_001305460

Mpeg1

macrophage expressed 1

1.14

2.19

−1.92

Metabolism

 NM_001080756

Car12

carbonic anhydrase 12

1.47

−1.32

1.94

 NM_001013882

Dctd

dCMP deaminase; 2 isoforms

−1.76

−1.22

−1.44

 NM_001191849

Ndst4

N-deacetylase/N-sulfotransferase 4

−1.30

1.29

−1.67

 NM_145084

Retsat

retinol saturase (all trans retinol 13,14 reductase)

−1.14

−2.69

2.37

Nucleic Acid Binding

 NM_001100653

Sidt1

SID1 transmembrane family, member 1

−1.44

1.16

−1.67

Protein Kinase/Phosphatase

 NM_019319

Mapk4

mitogen-activated protein kinase 4

1.37

−1.23

1.69

 NM_080394

Reln

reelin

1.81

1.06

1.72

Signal Transduction

 NM_012750

Gfra2

GDNF family receptor alpha 2

−1.05

1.60

−1.68

 NM_001106582

Gpr165

G protein-coupled receptor 165

−1.69

1.16

−1.96

 NM_021680

Nxph4

neurexophilin 4

1.96

1.24

1.58

 NM_019374

Pdyn

prodynorphin

2.56

1.12

2.28

 NM_017139

Penk

proenkephalin

1.31

−1.30

1.70

 NM_001107807

Pmepa1

prostate transmembrane protein, androgen induced 1

1.71

−1.05

1.80

 NM_133568

Rasd2

RASD family, member 2

1.30

−1.29

1.67

 NM_001106124

Slc39a12

solute carrier family 39 member 12

1.13

2.75

−2.42

 NM_001124768

Tac1

tachykinin, precursor 1; 5 isoforms

1.04

−1.69

1.75

Synaptic Plasticity

 NM_031984

Calb1

calbindin 1

1.78

−1.03

1.83

 NM_053988

Calb2

calbindin 2

−1.33

1.31

−1.75

 NM_024140

Nrgn

neurogranin

1.76

−1.02

1.80

 NM_030869

Nrp2

neuropilin 2

−2.00

−1.17

−1.70

Transcription

 XM_008770929

Dach1

dachshund family transcription factor 1

2.05

−1.01

2.07

 NM_203410

Ifi27

interferon, alpha-inducible protein 27

2.12

1.85

1.15

 NM_031069

Nell1

neural EGFL like 1

−1.49

1.16

−1.74

 XM_008763702

Nr4a3*

nuclear receptor subfamily 4, group A, member 3

1.32

−1.32

1.75

unclassified

 777675

Ighd2-5

Mm immunoglobulin heavy diversity 2–5

1.28

−2.31

2.96

  1. A gene was classified as significantly changed if it showed increased or decreased expression in SRvsCT, SSvsCT or SRvsSS comparisons according to an arbitrary cut-off at fold change ± 1.7, p < 0.05. Functional annotation and classification analyses for significantly changed genes were performed using DAVID Annotation tool16 (http://david.abcc.ncifcrf.gov) and were supported by literature searches.
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