Figure 4 | Scientific Reports

Figure 4

From: Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis

Figure 4

The effect of ST3GAL2 on myofibroblast activity and marker expression in fBMFs.

The sh-Luc.-expressing and sh-ST3GAL2-expressing fBMFs were subjected to in vitro migration and invasion assay, and the number of migration (a) and invasive (b) cells was calculated and is presented as the fold-change relative to sh-Luc.-expressing cells. (c) Single cell suspension of fBMFs infected with ST3GAL2-specific shRNA or control sh-Luc lentivirus was analyzed by wound healing assay. (d) The protein expression levels of α-SMA and COLA1 in fBMFs infected with ST3GAL2-specific shRNA or control sh-Luc lentivirus were analyzed by western blot. The original blots are shown in Supplementary Fig. 2. *P < 0.05 Sh-Luc.+fBMFs group versus Sh-Luc.+BMFs group; #P < 0.05 Sh- ST3GAL2 versus Sh-Luc. group.

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