Table 2 Enrichment and pathway analysis.

From: Analysis of Serum Metabolites to Diagnose Bicuspid Aortic Valve

Category

 

Total

Hits

P -value

Disease-associated

 

critical illness (cardiogenic shock)

6

3

0.0016

 

Lesch-Nyhan syndrome

5

2

0.0189

 

metabolites affected by exercise

5

2

0.0189

 

early markers of myocardial injury

14

3

0.0227

 

Crigler-Najjar syndrome | glucose-6-phosphate dehydrogenase deficiency | intoxication acetaminophen [dd] | pyruvate kinase deficiency

1

1

0.0464

Enzyme-associated

 

GMP reductase

6

3

0.0101

 

guanine phosphoribosyltransferase

6

3

0.0101

 

carnitine O-palmitoyltransferase

3

2

0.0212

 

Beta oxidation of fatty acid

3

2

0.0212

 

transport into the mitochondria (carnitine)

4

2

0.0400

 

methenyltetrahydrofolate cyclohydrolase

4

2

0.0400

 

carnitine transferase

4

2

0.0400

SNP-associated

 

rs10827283 | rs9663087

5

2

0.0385

 

rs1562861

5

2

0.0385

 

rs2039334

5

2

0.0385

Location-associated

 

skeletal muscle

45

4

0.0433

Pathway

 

Fatty acid biosynthesis

49

3

0.0052

 

Purine metabolism

92

3

0.0290

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