Figure 4 | Scientific Reports

Figure 4

From: A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse

Figure 4

Local sensitivity analysis for VEGF165a, VEGF165b and VEGF121.

The results show that VEGF165a in the disease compartment and VEGF165b in the blood compartment are more sensitive to VEGFR2 than VEGFR1, whereas VEGF121 in the disease and blood compartment is sensitive to both VEGFR1 and VEGFR2. VEGF165a, VEGF165b, VEGF121 are not sensitive to NRP1. The sensitivity analysis demonstrates the importance of VEGF165b-VEGFR2 binding.

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