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Figure 1

From: Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Figure 1

Experimental design.

BALB/c female mice were treated with isotretinoin, rapeseed oil (isotretinoin vehicle), metronidazole, doxycycline or water (antibiotics vehicle) by daily oral gavage for 2 weeks. (A) Splenic T-cells were isolated after 2 weeks of treatment (immediate effects) and after a recovery phase of 4 weeks after treatment cessation (long-term effects). For isotretinoin and rapeseed oil, 2-5 replicates (pool of 2-4 animals or no pooling) per group were sampled immediately after treatment and 2-5 replicates after the recovery phase. For metronidazole, doxycycline and water, 2 replicates (pool of 6 animals) were sampled per time point and group. (B) No differences between treatment groups were registered with respect to body weight for all time points.

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