Figure 2 | Scientific Reports

Figure 2

From: Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Figure 2

Correlation of predicted microRNA targets and mRNA expression directly after isotretinoin or antibiotic treatment in naive T-cells (direct effect).

Analysis of mathematically predicted microRNA targets was performed with TargetScan or TargetScan custom for (A) isotretinoin (iso), (B) metronidazole (metro) and (C) doxycycline (doxy) treated animals compared to control groups (left panels). Identification of differentially expressed mRNAs was performed with the following thresholds: |log2 (fold change)| ≥0.5, P-value ≤ 0.001 (right panels). Three of the most significant pathways associated with potentially up-regulated microRNA targets as predicted from down-regulated microRNAs and mRNAs are shown in the green sections whereas down-regulated microRNA targets (as predicted from up-regulated microRNAs) and mRNAs are depicted in the red sections. Shared candidates between predicted microRNA targets and experimentally derived mRNAs are displayed in the centers of the respective section. The pathway analysis was performed with MetaCore by Thomson Reuters.

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