Figure 5 | Scientific Reports

Figure 5

From: Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Figure 5

Correlation of predicted microRNA targets and mRNA expression after the recovery phase in Tregs of isotretinoin and antibiotic treated animals (long-term effect).

Analysis of mathematically predicted microRNA targets was performed with TargetScan or TargetScan custom for (A) isotretinoin (iso), (B) metronidazole (metro) and (C) doxycycline (doxy) treated animals compared to control groups (left panels). Selection of differentially expressed mRNAs was performed with the following thresholds: |log2 (fold change)| ≥0.5, P-value ≤ 0.001 (right panels). Three of the most significant pathways associated with up-regulated microRNA targets (down-regulated microRNAs) and mRNAs are shown in the green sections whereas down-regulated microRNA targets (up-regulated microRNAs) and mRNAs are depicted in the red sections. Shared candidates between predicted microRNA targets and experimentally derived mRNAs are displayed in the centers of the respective section. The pathway analysis was performed with MetaCore by Thomson Reuters.

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