Figure 8 | Scientific Reports

Figure 8

From: Targeted delivery system for cancer cells consist of multiple ligands conjugated genetically modified CCMV capsid on doxorubicin GNPs complex

Figure 8

Quantitative estimation of internalized drug delivery system in (a) MCF7 cells (Folate receptor positive FR+) and (b) HepG2 cells (Folate receptor negative FR−). (a) Without doxorubicin-conjugated folic acid positive (FA+DDS-red in graph) and negative (FA−DDS-blue in graph) drug delivery systems were used for study. Increased FA+DDS intake with time in MCF7 cells implicating the intake through receptor mediated endocytosis while cells incubated with FA−DDS (blue) did not show increase in internalization due to lack of folic acid on surface of DDS up to 60 min. (b) There was insignificant change in fluorescence of HepG2 cells along with both FA+DDS (red) and FA−DDS (blue) with time. This was due to negligible folic acid receptor on the surface of HepG2 cell lines. The initial static fluorescence were due to adsorption on the cell surface in both the cell lines.

Back to article page