Figure 2
Bicuculline and picrotoxin have similar inhibitory effects on radial neuron eIPSCs.
(a) Representative traces from a radial neuron superfused with 20 μM bicuculline (BIC) followed by 80 μM picrotoxin (PIC) from sham (grey, black) or PNL (pink, red) with plots showing eIPSC amplitude over time. (b) Amplitude of eIPSCs in the presence of bicuculline followed by picrotoxin for sham (grey, n = 8) and PNL (pink/red, n = 9) radial neurons. (c) Decay time constant of radial neuron eIPSCs following picrotoxin treatment normalized to the time constant following bicuculline treatment for sham (n = 8) and PNL (n = 9). Rise time of radial neuron eIPSCs following picrotoxin treatment normalized to the rise time following bicuculline treatment for sham (n = 8) and PNL (n = 9). (d). Normalized glycinergic eIPSC values (using bicuculline) as a percentage of the total eIPSC (n = 7 for each group). (*p < 0.05, paired t test).
