Figure 4
PNL reduces sIPSC frequency and increases decay time in radial neurons.
(a) Glycinergic sIPSC frequency of radial, vertical and central/islet cells from dorsal horn of control and nerve-injured animals (**p < 0.01, unpaired t tests). (b) Representative traces of glycinergic sIPSCs from control and nerve-injured radial neurons over a three minute period. (c) Amplitude histograms showing distribution of glycinergic sIPSC amplitudes over a 5 minute period for radial neurons from control and nerve-injured animals (n = 10 per group). Mean amplitudes for each cell are shown in the inset. (d) Representative traces of sIPSC events (average of 10 events) from control and nerve injured animals with fitted exponential shown in grey and a plot of decay time constants for both treatment groups (n = 10 per group). ***p < 0.001 (unpaired t tests).
