Table 1 Preliminary screening of mixed micelle formation with various ratios of different amphiphiles (NaDOC; TPGS; PLURONIC P123, F68, F87, F127, F108, and L121; CREMOPHOR RH40 and ELP) and lecithin.

From: Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin

Amphiphiles (HLB)

Curcumin:Lecithin:Amphiphile

1:0:5

1:1:5

1:0:10

1:1:10

1:0:20

1:1:20

NaDOC (16)

104.4 ± 2.23a (0.691 ± 0.045)b

91.1 ± 4.77 (0.564 ± 0.006)

109.9 ± 4.96 (0.498 ± 0.169)

78.8 ± 2.59 (0.294 ± 0.098)

111.6 ± 4.24 (0.327 ± 0.021)

132.7 ± 1.82 (0.308 ± 0.042)

TPGS (13)

145.9 ± 49.35c (1.457 ± 0.311)

286.9 ± 21.26 (1.250 ± 0.153)

44.3 ± 27.11 (−6.385 ± 5.218)

49.6 ± 2.98 (1.140 ± 0.109)

43.8 ± 1.20 (0.708 ± 0.181)

47.2 ± 6.54 (1.583 ± 0.040)

F68 ( > 24)

131.5 ± 10.60 (0.230 ± 0.039)

403.1 ± 83.86 (0.943 ± 0.192)

83.1 ± 23.36 (0.107 ± 0.062)

270.1 ± 6.86 (0.967 ± 0.022)

139.6 ± 59.21 (1.221 ± 0.437)

338.2 ± 10.73 (0.756 ± 0.084)

F108 ( > 24)

279.8 ± 203.15 (1.728 ± 0.176)

800.0 ± 20.98 (1.134 ± 0.132)

126.6 ± 28.23 (1.310 ± 0.559)

430.7 ± 10.12 (1.314 ± 0.023)

279.8 ± 203.15 (1.728 ± 0.176)

316.9 ± 5.00 (1.061 ± 0.014)

F87 ( > 24)

67.0 ± 3.62 (0.303 ± 0.093)

410.8 ± 5.32 (0.627 ± 0.052)

67.5 ± 11.12 (1.579 ± 0.069)

488.3 ± 38.48 (0.888 ± 0.084)

47.3 ± 21.23 (1.435 ± 0.136)

596.0 ± 118.27 (1.042 ± 0.044)

F127 (18–23)

92.1 ± 74.83 (−0.293 ± 1.562)

546.4 ± 95.08 (1.183 ± 0.250)

36.6 ± 5.89 (−0.060 ± 0.730)

421.3 ± 16.91 (0.905 ± 0.104)

244.6 ± 40.43 (1.680 ± 0.180)

322.9 ± 4.20 (1.419 ± 0.069)

L121 (1–7)

>3000

>3000

>3000

>3000

>3000

>3000

P123 (7–9)

111.2 ± 1.52 (0.334 ± 0.043)

106.1 ± 0.84 (0.820 ± 0.035)

85.1 ± 4.11 (1.236 ± 0.157)

622.8 ± 68.14 (1.881 ± 0.161)

69.1 ± 3.04 (1.376 ± 0.085)

257.8 ± 43.38 (2.116 ± 0.062)

RH40 (14.3)

257.4 ± 57.46 (−0.060 ± 0.037)

264.1 ± 73.32 (0.860 ± 0.313)

71.5 ± 101.12 (0.021 ± 0.353)

742.1 ± 87.89 (−3.450 ± 1.025)

43.0 ± 18.65 (1.294 ± 0.414)

208.9 ± 11.63 (1.960 ± 0.071)

ELP (13.9)

290.9 ± 6.50 (0.598 ± 0.031)

429.8 ± 9.48 (1.617 ± 0.017)

42.6 ± 36.48 (0.527 ± 0.666)

534.3 ± 206.48 (1.392 ± 0.174)

25.4 ± 11.79 (1.619 ± 0.174)

216.0 ± 1.14 (0.372 ± 0.024)

  1. aMean size ± SD.
  2. bMean PI ± SD.
  3. cUnderline stander for precipitation during 12 hr.
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