Table 3 Summary of pharmacokinetic parameters of curcumin following iv administration of lecithin-based mixed micelles (NaDOC and PLURONIC P123) and free curcumin or oral administration of lecithin-based mixed micelles (NaDOC and PLURONIC P123) and free curcumin (n = 3).
Treatment group | IVFree | IVP123a | IVNaDOCb | OralFree | OralP123a | OralNaDOCb |
|---|---|---|---|---|---|---|
Dose (mg/kg) | 5 | 5 | 5 | 100 | 100 | 100 |
kel (1/hr) | 0.17 ± 0.08 | 0.05 ± 0.04 | 0.03 ± 0.03 | 0.07 | 0.92 ± 1.44 | 0.25 ± 0.25 |
t1/2 (h) | 4.43 ± 1.56 | 16.80 ± 8.08 | 26.90 ± 13.33 | 10.41 | 4.94 ± 4.07 | 14.05 ± 20.49 |
Tmax (h) | 1.75 | 0.33 ± 0.14 | 0.25 ± 0.00 | |||
Cmax (μg/ml) | 0.004 ± 0.003 | 0.07 ± 0.02 | 0.06 ± 0.05 | |||
AUC0–72 (h.μg/ml) | 0.37 ± 0.15 | 0.86 ± 0.20 | 2.12 ± 1.53 | 0.03 ± 0.06 | 0.09 ± 0.017 | 0.15 ± 0.18 |
V (L/kg) | 91.28 ± 43.1 | 138.82 ± 62.73 | 100.83 ± 21.03 | 14387.49 | 7104.32 ± 5701.98 | 9931.80 ± 5739.07 |
CL (L/h/kg) | 14.69 ± 4.88 | 5.99 ± 1.35 | 3.19 ± 1.80 | 958.04 | 1109.8 ± 209.94 | 1549.76 ± 1154.73 |
Fab (%) | 100** | 232** | 573 | 0.4** | 1.2** | 2.0** |
Frel (%) | 100 | 300 | 500 |
