Figure 2
From: Identification of aberrant tRNA-halves expression patterns in clear cell renal cell carcinoma
Read length distributions demonstrate the presence of tRNA cleavage.
Read length distributions indicated the presence of two major peaks: a green peak indicates the enrichment of miRNA in the typical 20–24 nt fraction; a pink peak at 30–35 nt indicates the presence of 5′tRNA-halves. Exemplarily, the read length distribution of one corresponding pair of normal renal (A) and ccRCC (B) tissue is shown. It is important to note that the distribution of the read counts vary between the different corresponding samples. (C) the structure of tRNA4-Val-AAC is shown; it may be cleaved at the anticodon loop, resulting in 5′tRNA-halves of 30 to 35 nt, tRNA covariance model fold borrowed from Chan, P.P. & Lowe, T.M. (2009) GtRNAdb: A database of transfer RNA genes detected in genomic sequence. Nucl. Acids Res. 37(Database issue):D93-D97.
