Figure 2
Iontophoretic application of NMDA enhances bursting in DA-like neurons in the VTA and SNc in control but not NR1DATCreERT2 mice.
(a) Pie charts showing that NMDA induced an increase in the percentage of bursting DA-like neurons in the VTA and SNc of control animals, but a complete lack of NMDA-induced change in the proportion of bursting DA-like neurons in mutant mice. The numbers of neurons that were recorded are shown in brackets. (b–f) Graphs showing that NMDA induced an increase in most of the burst parameters that were generated by DA-like neurons in control animals, while NMDA induced no changes in burst parameters in mutant mice. Control animals: ● - baseline, ■ - NMDA; Mutant animals: ○ - baseline, □ - NMDA. Horizontal lines with whiskers indicate the mean and SEM of a parameter. Parameter values and statistics are shown in Supplementary Tables S4 and S5. ‘**’ Indicates Bonferroni’s multiple comparisons tests that resulted in p < 0.01, ‘***’ indicates p < 0.001 and ‘****’ indicates p < 0.0001.
