Figure 4
Saccharin preference tests and effort-based learning in an IntelliCage.
(a) The amount of saccharin and water drunk during 24 h saccharin preference test. (b) Saccharin preference in 24 h experiment in individual cages (Mann-Whitney, ns). (c–f) Experiments in an IntelliCage (c) Mean number of licks performed by animals in the saccharin and water corners under a fixed ratio 1 schedule. (d) Saccharin preference under a fixed ratio 1 schedule (ns). (e) Mean number of licks during effort-based test in an IntelliCage. (f) Saccharin preference during consecutive schedules of effort-based task. Group sizes were 7 controls & 8 mutant male mice in saccharin preference, 10 control & 13 mutant female mice in the saccharin preference test in the IntelliCage and 6 control & 8 mutant female mice in the effort-based test. Error bars show the s.e.m., ‘*’ indicates post-hoc test p < 0.05, ‘**’ or ‘##’ indicates p < 0.01, and ‘***’ indicates p < 0.001.
