Table 2 The identification of MRI61689 mutation.

From: A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice

Chromosome

Gene name

Location

Reference base

Variant base

Number of mutant mice with mutation

LOD score (Threshold: 2.08)

9

Acp5

22129643

C

A

(3/8)

−0.32

8

Kcnk1

126025024

C

T

(4/8)

0

17

Epas1

86825679

A

T

(0/8)

−2.33

7

Picalm

90165538

G

T

(0/8)

−2.33

18

Socs6

88869240

A

G

(5/8)

0.32

8

Ank1

23106019

T

A

(8/8)

2.33

  1. Six variants were selected from the exome sequencing, each mutation was sequenced in Ank-1(MRI61689/+) mice and the number of mutant mice carrying each mutation was determined and LOD score was calculated, with LOD threshold being 2.08 (n = 8).
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