Figure 7
Quantitative analysis of the transcripts from genes related to inflammation, fibrogenic and remodelling pathways.
D50 rats were born from dams fed a methyl donor deficient diet (iMDD) diet during pregnancy and lactation and subsequently subjected to high fat (HF) diet between D50 and D185. (A) The predominant changes (fold change higher than 2) were observed with Ccl11, Cxcr4, Il1b, Il1a and Nfkb1 for inflammatory genes. (B) Agt (angiotensinogen), Tgfb1, Tgfb2, Tgfb3 and Bmp7 (transforming growth factor beta super family), Vegfa (Vascular endothelial growth factor A) and Edn1 (endothelin 1) for genes involved in stellate cell activation. (C) Plat (plasminogen activator), Timp1, Timp2 and Timp4 (Tissue inhibitor of metalloproteases), Itga3 and Itgb8 (integrins) and Thbs2 (thrombospondin 2) for genes involved in extracellular matrix and cell adhesion; n = 4 in each group, means ± SD, *p < 0.05, **p < 0.01, ***p < 0.001.
