Figure 3 | Scientific Reports

Figure 3

From: Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies

Figure 3

BST2 depletion attenuates ADCC activities mediated by both CD4-induced and CD4-non-induced NAbs.

CEM CD4+ T cells expressing (NT) or depleted (SH) of BST2 were infected with CCR5-tropic NL4.3.ADA.IRES.GFP WT, N-U- or N-U-D368A viruses as indicated in Fig. 2 legend and examined for ADCC susceptibility mediated by (a) CD4-non-induced PGT126 or (b) CD4i 17b Abs as described in Fig. 1 legend. Panels a and b summarize results from at least 4 donors. In both Panels, paired, two-tailed Student’s t-tests, were used to compare the effect of BST2 depletion on ADCC activity with each virus.

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