Figure 5 | Scientific Reports

Figure 5

From: Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies

Figure 5

Enhancing physical tethering of HIV virions augments ADCC mediated by bNAbs in a BST2-dependent manner.

CEM CD4+ T cells expressing (NT) or depleted (SH) of BST2 were infected with CCR5-tropic NL4.3.ADA.IRES.GFP WT virus and treated with IFNα. Infected cells were analyzed for (a) BST2 and (b) Env expression, (c) ADCC susceptibility to PGT126 and (d) HIV particle release as described in Fig. 2 legend. Methodology and data analysis are as indicated in the legends for Figs 1 and 2. Each dot in Panel c represents one PBMC donor. Also in Panel c, Mann-Whitney U-tests were used to compare ranks between UT and IFN-treated groups for each cell type (NT or SH).

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