Figure 1 | Scientific Reports

Figure 1

From: Digital Detection of Exosomes by Interferometric Imaging

Figure 1

Schematic representation of the SP-IRIS detection process.

(A) SP-IRIS detection principle, monochromatic LED light illuminates the sensor surface and the interferometriclly enhanced nanoparticle scattering signature is captured on a CMOS camera. (B) Demonstrates SP-IRIS signal for polystyrene nanoparticles with a diameter from 50–200 nm which can be used to infer size of captured EVs. (C) Image of the SP-IRIS chip. (D) Low-magnification interferometric image showing microarray of immobilized capture probes. (E) SP-IRIS image of a capture probe. NVDX analysis software recognize capture spot and detects nanoparticles captured.

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