Figure 1
Behaviors in the juvenile offspring after prenatal poly(I:C) exposure.
(a): Schedule of treatment and behavioral tests. Saline or poly(I:C)(5 mg/kg/day from E12 to E17) was injected into pregnant mice. Behavioral tests including locomotion (LMT: D1) and novel object recognition test (NORT: D6 and D7) were performed. (b): Locomotion: There was no difference between ploy(I:C) offspring group and control group at juvenile stage. The value is expressed as the mean ± SEM. (n = 13 for control group, n = 19 for poly(I:C) group). (c): Novel object recognition test (NORT): the exploratory preferences were significantly lower in the poly(I:C) offspring than controls in the retention session, but there was no difference between the two groups in the training session. ***P < 0.001 compared with control group. The value is expressed as the mean ± SEM (n = 13 for control group, n = 18 for poly(I:C) group).
