Figure 1 | Scientific Reports

Figure 1

From: The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Figure 1

FTY720-P enhances TNF-induced PP2A phosphatase activity in A549 cells.

A549 cells were pretreated with 2.5 μM FTY720-P for 6 h, compared to vehicle-treated controls. Cells were treated with vehicle or TNF (4 ng/ml) and then PP2A enzymatic activity (measured as pmol free phosphate) detected at 1 h. Statistical analysis was performed using one-way ANOVA then Bonferroni’s post-test (where * denotes a significant effect of TNF compared to vehicle-treated cells, and § denotes a significant effect of FTY720-P on TNF-induced PP2A activity (P < 0.05)). Data are mean + SEM values from n = 3 independent experiments.

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