Figure 4 | Scientific Reports

Figure 4

From: The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Figure 4

S1P does not induce COX-2 mRNA expression, or PGE2 secretion.

A549 cells were pretreated with 2.5 μM FTY720 or FTY720-P for 6 h, compared to vehicle-treated controls. Cells were treated with vehicle or S1P (1 μM) and then (A) COX-2 mRNA expression measured at the indicated times (results expressed as fold increase compared to vehicle-treated cells at 0 h) and (B) secreted PGE2 at 24 h measured by enzyme immunoassay. Data are mean + SEM values from n = 3 independent experiments.

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