Table 10 Conformational epitopes of ZIKV-NS5 protein as predicted by ElliPro.

From: Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins

No

Residues

No. of residues

Score

1

N72, G73, V74, R76, L77, L78, S79, K80, P81, D83, V84, V85, T86, K466, L467, H468, L469, K470, D471, G472, R473, S474, R490, R500, F518, R521, L525, N528, A529, C531, S532, S533, V534, P535, V536, D537, W538, T556, T557, E558, D559, L561, V562, N565, R566, I569, E570, E571, N572, D573, H574, M575, E576, D577, K578, T579, P580, V581, T582, K583, W584, T585, D586, I587, P588, Y589, L596, G599, S600, L601, I602, G603, H604, P606, R607, T608, T609, W610, A611, E612, N613, I614, K615, N616, T617, V618, N619, M620, V621, R622, I624, I625, G626, D627, E628, E629, K630, Y631, M632, D633, Y634, L635, S636, T637, Q638, V639, R640, Y641

108

0.736

2

E3, E4, D5, V6, N7, L8, G9, S10, G11, T12, R13, A14, V15, V16, S17, C18, A19, E20, A21, P22, N23, M24, I26, I27, G28, N29, I31, E32, R33, I34, R35, S36, E37, H38, A39, E40, T41, W42, F43, F44, D45, E46, N47, H48, P49, Y50, R51, Y55, H56, G57, S58, Y59, E60, A61, P62, T63, Q64, T97, Y99, D110, R140, P141, R142, V143, C144, T145, K146, E147, I150, R154, E165, E166, K167, E168, W169, T171, V173, E174, A175, V176, N177, D178, P179, R180, F181, W182, A183, L184, V185, D186, K187, E188, R189, E190, H191, H192, L193, R194, G195, E196, C197, Q198, S199, C200, E237, T304, N305, Q306, M307, E308, K309, G310, H311, R312, A313, L314, L316, Y321, N325, R332, P333, A334, E335, K336, G337, K338, T339, V340

128

0.715

3

P116, Q117, E118, G119, T120, R121, Q122, V123, S125, M126, S129, W130, K133, E134, G136, K137, H138, K139, W247, S273, R274, I275, P276, G277, G278, R279, M280, Y281, N373, M374, E375, A376, E377, E378, V379, L380, E381, M382, Q383, D384, L385, W386, L387, L388, R389, R390, S391, E392, K393, V394, T395, N396, W397, L398, Q399, S400, N401, G402, W403, D404, R405, R408, K419, P420, I421, D422, D423, R424, A426, H427, A428, L429, R430, F431, D434, M435, T442, Q443, E444, W445, K446, P447, S448, T449, G450, W451, D452, N453

88

0.703

4

L590, G591, K592, R593, E594, W597

6

0.621

5

G494, A495, G496, W497, S498, I499

6

0.52

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