Table 1 Top 25 retinal genes sorted by P-value, following transmammary-delivered immunoblocking of BMP9 and BMP10.

From: A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

Gene Symbol

Ensembl Gene ID

Gene Description

Log Fold Change

Adjusted P-Value

Angpt2

ENSMUSG00000031465

angiopoietin 2

0.71358

2.69E-08

Ighv6-3

ENSMUSG00000076677

immunoglobulin heavy variable 6-3

0.97880

3.77E-08

Sarm1

ENSMUSG00000050132

sterile alpha and HEAT/Armadillo motif containing 1

1.19426

6.39E-08

Pfkp

ENSMUSG00000021196

phosphofructokinase, platelet

0.88318

9.18E-08

mt-Tw

ENSMUSG00000064346

mitochondrially encoded tRNA tryptophan

0.88100

9.00E-07

mt-Ta

ENSMUSG00000064347

mitochondrially encoded tRNA alanine

0.71786

1.02E-06

Col4a1

ENSMUSG00000031502

collagen, type IV, alpha 1

0.70214

1.18E-06

Gga3

ENSMUSG00000020740

golgi associated, gamma adaptin ear containing, ARF binding protein 3

0.98161

6.11E-06

Fitm2

ENSMUSG00000048486

fat storage-inducing transmembrane protein 2

0.97348

7.73E-06

Fam118b

ENSMUSG00000050471

family with sequence similarity 118, member B

1.00344

9.88E-06

mt-Tk

ENSMUSG00000064355

mitochondrially encoded tRNA lysine

0.91010

1.18E-05

Cd248

ENSMUSG00000056481

CD248 antigen, endosialin

0.87747

2.45E-05

Masp2

ENSMUSG00000028979

mannan-binding lectin serine peptidase 2

−1.03437

2.47E-05

Stab2

ENSMUSG00000035459

stabilin 2

−0.73237

2.76E-05

Fam160a2

ENSMUSG00000044465

family with sequence similarity 160, member A2

0.91040

2.76E-05

Gm13412

ENSMUSG00000085017

predicted gene 13412

1.11272

3.08E-05

Car10

ENSMUSG00000056158

carbonic anhydrase 10

2.50842

3.47E-05

4933431K23Rik

ENSMUSG00000086451

RIKEN cDNA 4933431K23 gene

0.93124

3.68E-05

Myo9a

ENSMUSG00000039585

myosin IXa

1.07037

4.02E-05

Entpd8

ENSMUSG00000036813

ectonucleoside triphosphate diphosphohydrolase 8

1.15946

4.45E-05

Cbx6

ENSMUSG00000089715

chromobox 6

0.75546

4.45E-05

Gm17828

ENSMUSG00000098893

predicted gene, 17828

−0.87768

4.84E-05

Khsrp

ENSMUSG00000007670

KH-type splicing regulatory protein

0.72962

4.84E-05

Col15a1

ENSMUSG00000028339

collagen, type XV, alpha 1

1.13494

5.05E-05

  1. The first 25 genes with adjusted P-value (false discovery rate) less or equal to 1% and abs(logFC) ≥ 0.7, sorted by increasing adjusted P-value, are shown. Gene expression changes are expressed in log2 fold change and compare anti-BMP9/10 Ab-treated versus control IgG2a/2b-treated retinas. Positive logFC values denote genes over-expressed in anti-BMP9/10 Ab-treated retinas. A log2 fold change value of 1 corresponds to a doubling of expression in treated retinas (log2(2) = 1).
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