Figure 1
Effect of irradiance on UVB-induced skin tumor.
The hairless mice were treated with high or LI UVB radiation at equivalent surface exposure (200 mJ/cm2) three times per week. (A) The number of skin tumors per mouse after indicated UVB treatment. (B) The representative presentation of dorsal mouse skin after 18 weeks of indicated UVB treatment. Left: control mouse; middle: high irradiance (HI) UVB treated mouse; right: low irradiance (LI) UVB treated mouse. (C) The tumor burden per mouse after 18 weeks of indicated UVB treatment. (D) The expression of mutant p53 in the normal-appearing skin of hairless mice after indicated UVB treatment. Representative presentation of immunohistochemical staining of p53 (PAb240 antibody) on dorsal skin of control (left), HI UVB treated (middle), and LI UVB (right) mice after 8 wks (top panel) and 18 wks (bottom panel) of indicated UVB treatment. (E) The quantitative analyses of mutant p53 expression on the dorsal skin of control, HI, and LI UVB treated mice after 8 wks and 18 wks of indicated UVB treatment. Scale bar indicates 100 μm. *Indicates p < 0.05.
