Table 3 The pooled data on survival of detailed analyses in blood or tissue subgroup.

From: Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis

Variables

Na

Caseb

Pooled data

Heterogeneity

HR (95% CI)

P

I 2

Ph

OS for tissue group

9

1412

0.604 (0.406, 0.899)

0.013

65.10%

0.003

By ethnicity

 Asian

8

757

0.567 (0.350, 0.918)

0.021

64.70%

0.006

 Caucasian

1

655

0.810 (0.594, 1.105)

0.184

—

—

By cancer

 Digestive system

5

979

0.890 (0.540, 1.467)

0.649

49%

0.095

 other

4

433

0.418 (0.302, 0.578)

<0.001

0%

0.422

By analysis

 MV

3

374

0.402 (0.266, 0.607)

<0.001

25.30%

0.252

 UV

6

1038

0.811 (0.518, 1.269)

0.359

47.60%

0.089

By case number

 >200

1

655

0.810 (0.594, 1.105)

0.810

—

—

 <200

8

757

0.567 (0.350, 0.918)

0.021

64.70%

0.006

By NOS score

 High quality

7

1244

0.575 (0.356, 0.928)

0.023

71.80%

0.002

 Low quality

2

168

0.718 (0.337, 1.528)

0.39

35.30%

0.214

OS for blood group

5

1900

1.624 (1.211, 2.177)

0.001

71.90%

0.007

By ethnicity

 Asian

4

1627

1.834 (1.564, 2.150)

<0.001

0

0.46

 Caucasian

1

273

0.890 (0.606, 1.307)

0.552

—

—

By cancer

 Digestive system

3

1489

1.519 (0.978, 2.359)

0.063

83.80%

0.002

 Other

2

411

1,805 (1.116, 2.919)

0.016

45.40%

0.176

By analysis method

 MV

4

1825

1.532 (1.122, 2.092)

0.007

76.10%

0.006

 UV

1

75

2.598 (1.284, 5.256)

0.008

—

—

By case number

 >200

4

1825

1.532 (1.122, 2.092)

0.007

76.10%

0.006

 <200

1

75

2.598 (1.284, 5.256)

0.008

—

—

By NOS score

 High quality

4

1825

1.532 (1.122, 2.092)

0.007

76.10%

0.006

 Low quality

1

75

2.598 (1.284, 5.256)

0.008

—

—

DFS for tissue group

3

362

0.593 (0.411, 0.857)

0.005

0%

0.546

By cancer

 Digestive system

2

303

0.626 (0.423, 0.927)

0.019

0%

0.44

 other

1

59

0.399 (0.138, 1.151)

0.089

—

—

By analysis method

 MV

1

194

0.660 (0.436, 0.999)

0.049

—

—

 UV

2

168

0.398 (0.178, 0.887)

0.024

0%

0.993

By NOS score

 High quality

1

194

0.660 (0.436, 0.999)

0.049

—

—

 Low quality

2

168

0.398 (0.178, 0.887)

0.024

0%

0.993

DFS for blood group

3

1488

1.582 (1.026, 2.439)

0.038

78.40%

0.01

By ethnicity

 Asian

2

1216

1.989 (1.598, 2.476)

<0.001

0%

0.712

 Caucasian

1

272

1.010 (0.690, 1.479)

0.959

—

—

By analysis

 MV

2

890

1.362 (0.749, 2.477)

0.311

77.60%

0.035

 UV

1

598

2.040 (1.578, 2.637)

<0.001

—

—

  1. aNumbers of studies included in the meta-analysis; bNumber of included patients.
  2. NOS: Newcastle-Ottawa Quality Assessment Scale; OS: overall survival; DFS: disease-free survival; HR: hazard ratio; MV: multivariate analysis; UV: univariate analysis; 95% CI: confidence interval; P: p value of pooled HR; I2: value of Higgins I-squared statistics; Ph: p value of Heterogeneity test.
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