Table 3 Type I error rates of four tests based on simulation set 1 for quantitative traits.

From: A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies

Number of Subpopulations

Test

Alpha

Un-corrected

GC

PC-linear

PC-nonp

2

Single Variant

0.01

0.1516

0.00414

0.01026

0.01038

0.001

0.05998

0.00032

0.00108

0.001

Regional

0.01

0.258

0.0081

0.00995

0.00925

0.001

0.1489

0.0004

0.00115

0.00095

10

Single Variant

0.01

0.0503

0.01498

0.01096

0.01068

0.001

0.01606

0.0026

0.0012

0.00108

Regional

0.01

0.0549

0.0101

0.0107

0.0102

0.001

0.0139

0.00085

0.0008

0.001

20

Single Variant

0.01

0.04896

0.02602

0.04234

0.01004

0.001

0.0214

0.0102

0.01632

0.00082

Regional

0.01

0.0488

0.01285

0.0391

0.011

0.001

0.0137

0.00255

0.0096

0.00075