Table 4 Type I error rates of five tests based on simulation set 1 for qualitative traits.

From: A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies

Number of Subpopulations

Test

Alpha

Un-corrected

GC

PC-linear

Biased Perm

PC-nonp

2

Single Variant

0.01

0.02914

0.00648

0.01124

0.0065

0.0107

0.001

0.00592

0.00034

0.00094

0.00056

0.00094

Regional

0.01

0.04066

0.00924

0.01168

0.0103

0.01192

0.001

0.0093

0.0009

0.00144

0.001

0.00146

10

Single Variant

0.01

0.0428

0.01106

0.0106

0.00672

0.0103

0.001

0.01172

0.00124

0.00162

0.00078

0.00138

Regional

0.01

0.04862

0.00984

0.0105

0.01034

0.01062

0.001

0.01174

0.00134

0.00128

0.0008

0.0012

20

Single Variant

0.01

0.02022

0.01244

0.01734

0.02296

0.01072

0.001

0.00414

0.00138

0.00354

0.00458

0.00132

Regional

0.01

0.04014

0.01068

0.03468

0.02694

0.01034

0.001

0.00952

0.00172

0.00746

0.0051

0.00152