Table 6 Type I error rates of five tests based on simulation set 2 for qualitative traits.

From: A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies

Model

Test

Alpha

Un-corrected

GC

PC-linear

BiasedPerm

PC-nonp

1

Single Variant

0.01

0.0384

0.0128

0.0409

0.02564

0.007

0.001

0.0132

0.0022

0.0151

0.00652

0.0005

Regional

0.01

0.0248

0.0095

0.0288

0.02752

0.0114

0.001

0.0056

0.0009

0.005

0.00584

0.0008

2

Single Variant

0.01

0.0453

0.0174

0.0087

0.00514

0.0088

0.001

0.0182

0.0048

0.0006

0.00032

0.001

Regional

0.01

0.0366

0.0115

0.0121

0.00684

0.0093

0.001

0.0078

0.0007

0.0016

0.00046

0.0012