Figure 3
From: Protein-peptide molecular docking with large-scale conformational changes: the p53-MDM2 interaction
Protein-peptide contact analysis.
All panels (a–c) show averaged results from CABS-dock docking (over 10,000 models). Panel (a) presents frequencies of contact formation by p53 peptide residues, histogram (b) presents frequencies of contact formation by MDM2 residues (the green and blue bars mark the lid and binding site regions of the receptor, respectively). The binding site and the lid residues that contact the peptide most frequently are marked. Panel (c) shows a contact frequency map between residues from MDM2 and the p53 peptide together with native contacts marked in green for reference.
