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Figure 1

From: Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model

Figure 1

Multi-Omics MGM of Age.

Each node in the graph represents one age-related variable. Omics markers were selected according to literature from epigenomics (purple), transcriptomics (brown), glycomics (red) and metabolomics (orange) datasets and combined with DXA measurements (green) and other clinical phenotypes (yellow). Edges between nodes were inferred using a mixed graphical model approach, and thus indicate the conditional dependence between variables; the color represents positive (red) and negative (blue) correlation. An unbiased cluster detection algorithm was used to identify densely connected modules within the network, indicated by grey borders.

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